“Grey’s Anatomy” fans can breathe again knowing the show premieres this week.

The long-running medical drama will air its midseason premiere on Thursday, picking up after its gut-wrenching Season 21 cliffhanger in the fall.

In true “Grey’s” fashion, the episode ended with Jo Wilson (Camila Ludington) getting shot following an armed store robbery while going into labor. The midseason premiere will pick up in the aftermath of shooting at Grey Sloan Memorial Hospital, where Jo’s romantic partner Atticus Lincoln (Chris Carmack) is working, unaware of what happened.

The episode will also follow Ben Warren (Jason Winston George) facing roadblocks “with his new emergency preparedness plan,” romantic tensions for Owen Hunt (Kevin McKidd), as well as a surgical plan dispute between doctors Amelia Shepherd (Caterina Scorsone) and Dr. Winston Ndugu (Anthony Hill).

Here’s what to know about the “Grey’s Anatomy” Season 21 midseason premiere this week.

Caterina Scorsone as Dr. Amelia Shepherd, Harry Shum Jr. as Dr. Benson “Blue” Kwan, and Anthony Hill as Dr. Winston Ndugu in the new episode of “Grey’s Anatomy” premiering Thursday, March 6, 2025.

When does the next episode of ‘Grey’s Anatomy’ come out?

“Grey’s Anatomy” returns for the Season 21 midseason premiere on Thursday, March 6, at 10 p.m. in all U.S. time zones on ABC.

How to watch ‘Grey’s Anatomy’ Season 21

New episodes of “Grey’s Anatomy” Season 21 will air on ABC. Fans can also stream the episode on Hulu on Friday morning.

The first 20 seasons of the series are available to stream on both Netflix and Hulu. Netflix typically adds new seasons of “Grey’s Anatomy” after a season wraps up, and the same is expected for Season 21.

Chandra Wilson as Dr. Miranda Bailey and Chris Carmack as Dr. Atticus Lincoln in the new episode of “Grey’s Anatomy” premiering Thursday, March 6, 2025.

How many episodes of ‘Grey’s Anatomy’ Season 21 will there be?

Season 21 of “Grey’s Anatomy” will have 18 episodes, an increase from only 10 episodes in Season 20.

Last season was shortened by the actors’ and writers’ strikes of 2023. The medical drama typically premieres new seasons in the fall and concludes in the spring.

Is Meredith Grey back on ‘Grey’s Anatomy’?

Meredith Grey (Ellen Pompey) will appear in at least seven of Season 21’s 18 episodes, Deadline reported, citing anonymous sources.

Ellen Pompeo as Dr. Meredith Grey on Season 21 of “Grey’s Anatomy.”
In August 2022, Pompeo announced she would have a limited appearance on Season 19 and has continued to be in a small portion of seasons since. However, she continues to serve as an executive producer and offer her staple voiceover narrations in each episode.

What year did ‘Grey’s Anatomy’ start?

“Grey’s Anatomy” debuted its first episode, titled “A Hard Day’s Night,” on ABC on March 27, 2005.

The series pilot chronicled the first day of five surgical interns at Seattle Grace Hospital, and the series has since followed the personal and professional lives of staff at the center now named Grey Sloan Memorial Hospital.